Your key to the Gateway City...welcome to the Hampton Inn St. Louis-I-44 Southwest, MO.St. Louis has long been known as the Gateway City, given its railroading past and history as the jumping point to the American West. Stay at the Hampton Inn® hotel in St. Louis-I-44 Southwest, MO, and you'll understand how the city's location has been so pivotal in its development. Like St. Louis itself, our hotel takes advantage of its convenient location. Within just minutes, you can be exploring a magic museum, riding a roller coaster, or at one of the nation's top petting zoos. While you're here, don't miss a trip into downtown St. Louis. It's just 18 miles from the Hampton Inn hotel in St. Louis-I-44 Southwest. Once there, you'll find the Gateway Arch, a masterpiece of precision crafted in stainless steel. Also, you won't want to miss the shopping and dining at Union Station, which has been beautifully restored to its 19th-century splendor. So come check into the Hampton Inn hotel in St. Louis-I-44 Southwest, your key to the Gateway City.