old world charm meets Midwest hospitality...welcome to the Hampton Inn and Suites-St. Louis South I-55 hotel.When you book the Hampton Inn and Suites St Louis/South I-55 hotel, you'll soon understand why the hotel is ranked #1 of all hotels in St. Louis based on TripAdvisor reviews! You'll love the mix of Old World charm and Midwest hospitality that characterizes the vibrant city of St. Louis. From the moment you're greeted by its signature Gateway Arch, you'll be glad you booked a stay at our Hampton Inn and Suites® St. Louis/South I-55 hotel near St. Louis downtown. After you check in, it will be hard to decide what to do first. Experience views from atop the Gateway Arch? Explore fabulous museums? Visit the St. Louis Zoo? We're close to the best that the city has to offer.View our St. Louis hotel packages and specialsEnjoy your extended stay in St. Louis with our beautiful hotel suites Explore historic Union Station or catch a game at Busch Stadium, home of the St. Louis Cardinals. The former industrial area of Laclede's Landing is now a bustling entertainment district that features live music, ranging from pop to jazz, dining and more.The Soulard neighborhood boasts jazz and bl
