Hampton Inn & Suites St. Louis/South I-55

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Accommodation VIP Access ★ ★ ★ ★ ★

Hampton Inn & Suites St. Louis/South I-55

Jul 10, 2026 (3 nights)

Tranquil elegance in vibrant SAINT LOUIS, MO

Old World Charm Meets Midwest Hospitality...Welcome To The Hampton Inn And Suites-St. Louis South I-55 Hotel.When You Book The Hampton Inn And Suites St Louis/South I-55 Hotel, You'll Soon Understand Why The Hotel Is Ranked #1 Of All Hotels In St. Louis Based On Tripadvisor Reviews! You'll Love The Mix Of Old World Charm And Midwest Hospitality That Characterizes The Vibrant City Of St. Louis. From The Moment You're Greeted By Its Signature Gateway Arch, You'll Be Glad You Booked A Stay At Our Hampton Inn And Suites® St. Louis/South I-55 Hotel Near St. Louis Downtown. After You Check In, It Will Be Hard To Decide What To Do First. Experience Views From Atop The Gateway Arch? Explore Fabulous Museums? Visit The St. Louis Zoo? We're Close To The Best That The City Has To Offer.View Our St. Louis Hotel Packages And Specialsenjoy Your Extended Stay In St. Louis With Our Beautiful Hotel Suites Explore Historic Union Station Or Catch A Game At Busch Stadium, Home Of The St. Louis Cardinals. The Former Industrial Area Of Laclede's Landing Is Now A Bustling Entertainment District That Features Live Music, Ranging From Pop To Jazz, Dining And More.The Soulard Neighborhood Boasts Jazz And Bl

4200 MIDAMERICA LANE

Nearby highlights

Choose Your Room

Please select another date. The maximum allowed date range is 15 days.

2 QUEEN BEDS NONSMOKING...FREE WI-FI/32

★ ★ ★ ★ ★

Old World Charm Meets Midwest Hospitality...Welcome To The Hampton Inn And Suite...

4200 MIDAMERICA LANE

Breakfast included - Refundable $0

Refundable

Breakfast included

$ 585.62 total
$ 195.21 per night
Taxes & fees Included

2 QUEENS MOBILITY/HEARING ACCESS TUB NO

★ ★ ★ ★ ★

Old World Charm Meets Midwest Hospitality...Welcome To The Hampton Inn And Suite...

4200 MIDAMERICA LANE

Breakfast included - Refundable $0

Refundable

Breakfast included

$ 585.62 total
$ 195.21 per night
Taxes & fees Included

1 KING BED STUDIO SUITE NONSMOKING...FR

★ ★ ★ ★ ★

Old World Charm Meets Midwest Hospitality...Welcome To The Hampton Inn And Suite...

4200 MIDAMERICA LANE

Breakfast included - Refundable $0

Refundable

Breakfast included

$ 633.77 total
$ 211.26 per night
Taxes & fees Included

1 KING STUDIO SUITE W/WHIRLPOOL NONSMOK

★ ★ ★ ★ ★

Old World Charm Meets Midwest Hospitality...Welcome To The Hampton Inn And Suite...

4200 MIDAMERICA LANE

Breakfast included - Refundable $0

Refundable

Breakfast included

$ 649.84 total
$ 216.61 per night
Taxes & fees Included

Policies & guest information

Tip: Select a rate on the right side of the room card (Refundable / Non-Refundable). This section will instantly update to show the exact cancellation policy for the selected rate.

Check-in

Standard check-in time: 03:00PM

Check-out

Standard check-out time: 11:00AM

Need help?

For questions about your booking or policies, contact us at +1 305 428-2518.

Cancellation policy (selected rate)

Updates when you change the rate

Select a rate to see the policy.

The terms shown here apply to the rate you selected on the room card. If you switch rates, the policy will change accordingly.

Important information:

Additional-person charges may apply and vary according to the property’s policy.
Government-issued photo ID and a credit/debit card or cash deposit may be required at check-in.
Special requests are subject to availability at check-in and may incur additional charges; they cannot be guaranteed.
This property accepts credit cards, debit cards, and cash. A pre-authorization may be requested prior to arrival. Parties and events are allowed (including weddings, birthdays, and family gatherings). Long stays are permitted. Safety measures include smoke detectors and exterior lighting. Some outdoor areas (balconies, terraces, patios) may not be suitable for children. Please contact the property in advance to confirm room suitability.

Important payment information

Some fees related to payment processing (such as transaction or card-processing costs) are non-refundable, even if your booking is later modified or canceled.
Any bank or card-issuer fees for international transactions or currency conversion are charged directly by your bank and are not covered by ThatVacation.com.
In the event of cancellation, any non-refundable fees already incurred will be excluded from any refund.
If you make changes to your booking, the new price will be based on the rates available at the time of the change and may differ from your original booking.
Some bookings may have specific cancellation or change restrictions; please review the property’s policy before making a reservation.

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				<desc><![CDATA[old world charm meets Midwest hospitality...welcome to the Hampton Inn and Suites-St. Louis South I-55 hotel.When you book the Hampton Inn and Suites St Louis/South I-55 hotel, you'll soon understand why the hotel is ranked #1 of all hotels in St. Louis based on TripAdvisor reviews! You'll love the mix of Old World charm and Midwest hospitality that characterizes the vibrant city of St. Louis. From the moment you're greeted by its signature Gateway Arch, you'll be glad you booked a stay at our Hampton Inn and Suites® St. Louis/South I-55 hotel near St. Louis downtown. After you check in, it will be hard to decide what to do first. Experience views from atop the Gateway Arch? Explore fabulous museums? Visit the St. Louis Zoo? We're close to the best that the city has to offer.View our St. Louis hotel packages and specialsEnjoy your extended stay in St. Louis with our beautiful hotel suites Explore historic Union Station or catch a game at Busch Stadium, home of the St. Louis Cardinals. The former industrial area of Laclede's Landing is now a bustling entertainment district that features live music, ranging from pop to jazz, dining and more.The Soulard neighborhood boasts jazz and bl]]></desc>
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